Longevity-Cognitive-Aging

Brain Changes: Volume, Connectivity, and Gray-White Matter Contrast
The aging brain undergoes a cascade of structural changes — subcortical volumes shrink, functional connectivity networks reorganize, and the boundar…
Cognitive Trajectory Modeling
Most research on cognitive aging relies on either cross-sectional comparisons — snapshots of cognition at a single time point — or pre-defined cli…
Diet and Brain Health
What we eat shapes not only our metabolic health but, increasingly, appears to influence brain structure and function across the lifespan. Dietary pat…
Digital Twins for Personalized Cognitive Intervention
Identifying individuals at risk of cognitive decline is only half the problem. The other half — and arguably the harder half — is determining what…
Impact of Physical Load on Cognitive Performance
Physical activity is widely recognized as one of the most robust modifiable protective factors against cognitive decline. But the relationship between…
Lithium Level and AD/MCI Onset
Lithium has been used for decades as a mood stabilizer in bipolar disorder, but a growing body of epidemiological evidence suggests it may also confer…
Longevity and Centenarian Survivorship
Centenarians are statistical outliers — individuals who have survived to the extreme tail of the human lifespan. While genetics undoubtedly plays a …
Metabolomic Signatures of AD in Type-2 Diabetes
Type-2 diabetes approximately doubles the risk of Alzheimer’s disease. This association is well established epidemiologically, but the specific metabo…
Obesity, Insulin Resistance, and Neural Processing
The relationship between metabolic health and brain function is typically studied in older adults, often after cognitive decline has already begun. Bu…
Super-Agers and Positive-Agers
Not everyone ages the same way. While cognitive decline is common in older adults, a remarkable subset — often called “Super-Agers” or “Positive-Age…